Die Wissenschaft der Hautregeneration

PDRN stands for Polydeoxyribonucleotide — a purified mixture of DNA fragments extracted from salmon sperm cells, with molecular weights of 50–1,500 kDa. It is the key active ingredient in Korean skincare products like serums, creams, masks, and injectable skin boosters that promote skin regeneration through the adenosine A2A receptor pathway.

PDRN benefits for skin include stimulating collagen production (Types I and III), promoting tissue repair and wound healing, reducing inflammation, improving skin hydration and elasticity, brightening dark circles, and supporting anti-aging. Clinical studies show visible improvements in fine lines and skin texture after 3–4 PDRN treatment sessions.

Yes, PDRN and retinol can be used together, but it is best to apply them at different times. Use retinol in your evening routine and PDRN serum in the morning, or alternate nights. If using PDRN after a retinol-based treatment like microneedling, wait until any irritation subsides. PDRN's anti-inflammatory properties can actually help soothe retinol-sensitized skin.

Emerging research suggests PDRN can stimulate hair follicle regeneration by activating A2A receptors on dermal papilla cells, promoting scalp microcirculation and growth factor expression. PDRN hair ampoules and scalp treatments are gaining popularity in Korean clinics, though more large-scale clinical trials are needed to confirm long-term efficacy for hair loss.

PDRN injectable treatment costs vary by region: $200–$500 per session in South Korea, $300–$800 in Southeast Asia, and $500–$1,200 in Western countries. A full course of 3–4 sessions typically costs $600–$3,000+. Over-the-counter PDRN skincare products (serums, creams, masks) range from $15–$80 depending on the brand and concentration.