Full-Face PDRN Skin Booster Treatment Protocol

Overview

This protocol describes the standard approach for full-face PDRN skin booster treatment using the nappage (microinjection) technique. It is intended as a clinical reference for trained practitioners and is based on published protocols and consensus guidelines from Korean and European dermatology societies.

Patient Selection

Indications

• Mild to moderate photoaging (Glogau II-III)
• Skin dullness, rough texture, and loss of elasticity
• Fine lines and superficial wrinkles
• Skin dehydration and impaired barrier function
• Post-procedural skin quality maintenance

Contraindications

• Active skin infection at treatment site
• Known hypersensitivity to fish-derived products
• Pregnancy or breastfeeding
• Autoimmune connective tissue disease (relative)
• Anticoagulant therapy (relative — assess bleeding risk)

Pre-Treatment Preparation

1. Consultation — Assess skin condition, discuss realistic expectations, obtain informed consent, and photograph baseline status under standardized lighting.
2. Skin preparation — Cleanse the face thoroughly with a gentle antiseptic (chlorhexidine 0.05% or equivalent). Remove all makeup and sunscreen.
3. Anesthesia — Apply topical anesthetic cream (lidocaine 2.5%/prilocaine 2.5%) under occlusion for 20-30 minutes prior to treatment. Remove and re-cleanse before injection.

Injection Technique

Equipment

• PDRN skin booster product (e.g., Rejuran Healer 2 mg/mL, 2 mL syringe)
• 30G or 32G needle (4 mm or 13 mm length)
• Sterile gauze and post-treatment soothing mask

Nappage Technique

1. Injection depth — Target the superficial dermis (papillary to upper reticular dermis), approximately 1-2 mm below the skin surface.
2. Volume per point — 0.01-0.02 mL per injection, creating a small dermal wheal at each point.
3. Spacing — Injection points spaced 5-10 mm apart in a grid pattern across the treatment area.
4. Coverage zones — Divide the face into zones (forehead, temples, periorbital, cheeks, nasolabial, perioral, jawline, chin) and treat systematically.
5. Total volume — 2 mL distributed across the full face per session (approximately 100-200 injection points).
6. Needle angle — Insert the needle at 10-30 degrees to the skin surface with bevel facing upward.

Treatment Schedule

Phase	Sessions	Interval	Purpose
Induction	3-4 sessions	Every 2-4 weeks	Build collagen and tissue repair response
Maintenance	1 session	Every 3-6 months	Sustain rejuvenation results

Post-Treatment Care

1. Immediate — Apply gentle pressure with sterile gauze to control any pinpoint bleeding. Soothing mask application for 15-20 minutes is recommended.
2. First 24 hours — Avoid touching the face, applying makeup, or engaging in vigorous exercise. Mild erythema and papules at injection sites are normal and typically resolve within 24-48 hours.
3. First week — Use gentle cleanser and moisturizer only. Avoid active skincare ingredients (retinoids, AHAs, vitamin C serums). Apply broad-spectrum SPF 50+ sunscreen daily.
4. Ongoing — Resume normal skincare routine after 1 week. Encourage consistent sun protection to preserve treatment benefits.

Expected Outcomes

Progressive improvement in skin texture, elasticity, hydration, and radiance over the treatment course. Initial effects (improved hydration, glow) are often noted within 1-2 weeks of the first session. Collagen remodeling effects continue for 2-3 months after completing the induction phase. Patient satisfaction scores in published studies consistently exceed 80% at the 12-week endpoint.