c-PDRN serves as the primary bioactive compound in PDRN skin boosters and injectables. It activates the adenosine A2A receptor (ADORA2A), triggering Gs-coupled GPCR signaling that elevates cAMP levels and promotes fibroblast proliferation, collagen synthesis (Types I and III), anti-inflammatory cascades (NF-κB suppression), and angiogenesis via VEGF upregulation. It also provides nucleotide building blocks through the salvage pathway, supporting tissue repair at the cellular level.c-PDRN (Concentrated Polydeoxyribonucleotide)
c-PDRN is a highly purified, concentrated form of polydeoxyribonucleotide — fragmented double-stranded DNA extracted from salmon (Oncorhynchus keta) sperm cells. The 'c' designation indicates a concentrated preparation optimized for injectable aesthetic applications, with molecular weight ranging 50–1,500 kDa and >95% nucleic acid purity.
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