Kompleksowy słownik terminologii PDRN, polinukleotydów i dermatologii regeneracyjnej — kluczowe definicje dla specjalistów medycyny estetycznej i badaczy.
A G-protein coupled receptor expressed on fibroblasts, endothelial cells, and immune cells. When activated by PDRN or adenosine, it elevates intracellular cAMP levels, promoting cell proliferation, collagen synthesis, angiogenesis, and suppression of pro-inflammatory cytokines. It is the primary molecular target of PDRN-based therapies.
Read more →The formation of new blood vessels from pre-existing vasculature. PDRN promotes angiogenesis by activating A2A receptors on endothelial cells, leading to upregulation of vascular endothelial growth factor (VEGF). This is particularly important in wound healing, treatment of ischemic ulcers, and revitalization of photoaged skin with compromised microcirculation.
A family of structural proteins that form the primary scaffolding of the dermis, providing tensile strength and resilience to the skin. Types I and III are the most abundant in skin. PDRN promotes synthesis of both collagen types by activating dermal fibroblasts, contributing to improved skin firmness and elasticity.
The principal cell type of the dermis, responsible for synthesizing the extracellular matrix components that give skin its structure and elasticity. Fibroblasts produce collagen, elastin, glycosaminoglycans, and growth factors. PDRN stimulates fibroblast proliferation and biosynthetic activity through A2A receptor activation.
A unit of molecular mass equal to 1,000 daltons, used to describe the size of biological molecules. In the context of PDRN and polynucleotides, molecular weight (expressed in kDa) is the key distinguishing factor: PDRN ranges from 50 to 1500 kDa, while polynucleotides exceed 1500 kDa. Higher molecular weight correlates with greater viscoelasticity and slower degradation.
A minimally invasive technique involving multiple superficial intradermal microinjections to deliver active ingredients directly into the mesoderm (middle layer) of the skin. In PDRN therapy, mesotherapy refers to the delivery method used to administer skin boosters across a treatment area using fine-gauge needles.
The South Korean government agency responsible for regulating food, pharmaceuticals, medical devices, and cosmetics. MFDS approval is the regulatory standard for PDRN products marketed in South Korea, including the Rejuran product line. It is analogous to the FDA in the United States or the EMA in Europe.
A mesotherapy injection method in which multiple small-volume injections (0.01-0.02 mL each) are placed in a grid pattern across the treatment area at consistent spacing (5-10 mm apart). The nappage technique ensures even distribution of the product throughout the dermis and is the standard delivery method for PDRN skin boosters.
A purified mixture of DNA fragments with molecular weights ranging from 50 to 1500 kDa, extracted from salmon sperm cells. PDRN activates the adenosine A2A receptor pathway, stimulating tissue regeneration, collagen synthesis, and anti-inflammatory responses. It is the active ingredient in skin boosters such as Rejuran Healer.
Read more →A high-molecular-weight biopolymer (>1500 kDa) composed of long chains of deoxyribonucleotides, typically extracted from trout gonads. Polynucleotides share the same A2A receptor-mediated mechanism as PDRN but exhibit greater viscoelastic properties due to their longer chain length, providing bioscaffolding effects in addition to biostimulation.
A metabolic pathway that recycles nucleotides and nucleosides from degraded DNA and RNA, converting them back into usable building blocks for new nucleic acid synthesis. PDRN fragments, once degraded by tissue nucleases, feed into the salvage pathway, providing metabolic substrates to energy-depleted cells without the cost of de novo nucleotide synthesis.
A category of injectable treatments designed to improve overall skin quality — hydration, texture, elasticity, and radiance — rather than add volume or reduce wrinkles. PDRN and polynucleotide skin boosters work by stimulating the skin's own regenerative processes through A2A receptor activation and nucleotide supplementation.
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