PDRN Carec-PDRN (Concentrated Polydeoxyribonucleotide)
What is it?
c-PDRN is a highly purified, concentrated form of polydeoxyribonucleotide — fragmented double-stranded DNA extracted from salmon (Oncorhynchus keta) sperm cells. The 'c' designation indicates a concentrated preparation optimized for injectable aesthetic applications, with molecular weight ranging 50–1,500 kDa and >95% nucleic acid purity.
Role in PDRN
c-PDRN serves as the primary bioactive compound in PDRN skin boosters and injectables. It activates the adenosine A2A receptor (ADORA2A), triggering Gs-coupled GPCR signaling that elevates cAMP levels and promotes fibroblast proliferation, collagen synthesis (Types I and III), anti-inflammatory cascades (NF-κB suppression), and angiogenesis via VEGF upregulation. It also provides nucleotide building blocks through the salvage pathway, supporting tissue repair at the cellular level.
Clinical Data
Multiple RCTs demonstrate statistically significant improvements in skin elasticity, hydration, and wrinkle depth with c-PDRN injections. A 2019 randomized controlled trial showed 23% improvement in skin elasticity after 4 sessions. Safety profile is excellent with no serious adverse events reported in published literature. Most common side effects are transient injection-site erythema and mild swelling.
Found in These Products
Rejuran Healer
Pharmaresearch Products
The original Korean PDRN skin booster — c-PDRN derived from salmon DNA for skin rejuvenation and barrier repair.
Rejuran S
Pharmaresearch Products
Targeted PDRN scar treatment injectable — higher viscosity c-PDRN formulation designed for atrophic acne scars and surgical scar remodeling.