Question 1

Are Rejuran and Mastelli interchangeable for practitioners?

Accepted Answer

While both deliver salmon-derived PDRN through intradermal injection and work via the same A2A receptor activation mechanism, they are not directly interchangeable in practice. Each product has its own viscosity, concentration, and injection protocol specifications. Practitioners are trained on specific product systems, and regulatory approval varies by country. A practitioner experienced with Rejuran would need familiarization with Mastelli's specific parameters and vice versa. Both achieve comparable clinical outcomes when used according to their respective protocols.

Question 2

Which has stronger clinical evidence?

Accepted Answer

Rejuran has a larger body of published clinical trials, particularly from Korean and Japanese dermatology journals, with specific data points like the 23% elasticity improvement after four sessions measured by cutometer, and ultrasound-verified skin thickness increases. Mastelli has solid European clinical data supporting its efficacy. The difference in published evidence volume partly reflects Rejuran's earlier entry into the market and the higher volume of aesthetic medicine research published in Korean journals. Both brands have sufficient clinical evidence to support their use by trained professionals.

Question 3

Can I combine injectable PDRN (Rejuran or Mastelli) with topical PDRN products?

Accepted Answer

Yes, and many dermatologists recommend this approach. Injectable PDRN treatments (whether Rejuran or Mastelli) provide periodic intensive dermal-level regeneration, while topical PDRN products from brands like Medicube, COSRX, or Anua provide daily epidermal-level maintenance between clinical sessions. The injectable and topical approaches are complementary — they work at different skin depths and provide different durations of benefit. Your dermatologist can recommend a combined protocol tailored to your skin's needs.

Question 4

What is the difference between Rejuran Healer, S, I, and HB?

Accepted Answer

Rejuran Healer is the original all-purpose skin booster (0.2% c-PDRN, standard viscosity) for overall skin rejuvenation, firmness, and elasticity — it is the most widely used variant and the best starting point for first-time patients. Rejuran S has a higher viscosity formulation that targets acne scars and textural irregularities by depositing concentrated PDRN directly into scar tissue for localized dermal repair. Rejuran I uses a thinner, lower-viscosity formulation specially designed for the delicate, ultra-thin periorbital skin to address dark circles, fine lines, and under-eye hollowing. Rejuran HB combines c-PDRN with non-crosslinked hyaluronic acid for dual-action hydration and regeneration, ideal for severely dehydrated or post-procedure skin. Your dermatologist will recommend the most appropriate variant based on your specific skin concerns and treatment goals.

Question 5

Is Rejuran the same as topical PDRN skincare products?

Accepted Answer

No, Rejuran products are fundamentally different from topical PDRN skincare. Rejuran products are clinical-grade injectable skin boosters administered by trained medical professionals (dermatologists and aesthetic physicians) in clinical settings using microinjection techniques. While topical PDRN products offer genuine benefits through surface and upper-epidermal penetration, Rejuran delivers c-PDRN directly into the papillary dermis where A2A receptors are most concentrated, achieving maximum bioavailability and significantly more dramatic results in skin thickness (measurable by ultrasound), elasticity (measurable by cutometer), and deep tissue repair. The two approaches are complementary: many patients use Rejuran injections for periodic intensive treatment and topical PDRN products for daily maintenance between clinical sessions.

Question 6

How often should Rejuran treatments be done?

Accepted Answer

A typical Rejuran treatment protocol involves an initial course of three to four sessions spaced two to four weeks apart, which allows each treatment to build on the collagen synthesis and tissue remodeling initiated by the previous session. Most patients begin noticing visible improvements in skin texture and elasticity after the second session. After completing the initial course, maintenance treatments are recommended every three to six months depending on individual skin condition, age, environmental exposure, and treatment goals — younger patients with mild concerns may need maintenance only every six months, while older patients or those in harsh environments may benefit from quarterly sessions. A board-certified dermatologist will assess your skin and provide a personalized treatment plan during your initial consultation.

Aspect	Rejuran	Mastelli
Regulatory Standard	Korean MFDS (Ministry of Food and Drug Safety) approved medical device for aesthetic use	CE-certified European medical device manufactured under EU pharmaceutical GMP standards
Product Specialization	Four variants: Healer (all-purpose), S (acne scars), I (periorbital), HB (hydration + HA)	Plinest line with specialized formulations for face and body areas
PDRN Source & Concentration	Salmon-derived c-PDRN at 0.2% (2 mg/mL) with proprietary purification technology	Salmon-derived PDRN manufactured under European pharmaceutical purification protocols
Geographic Dominance	Market leader in South Korea, Japan, Singapore, Thailand, and expanding across Asia	Established presence across Europe, Middle East, and expanding into Asian markets
Clinical Evidence	Extensive published trials showing 23% elasticity improvement after four sessions; ultrasound-verified thickness gains	European clinical data supporting PDRN efficacy for tissue repair and skin rejuvenation
Pioneer Status	Inventor of the PDRN skin booster category; holds foundational c-PDRN injection patents	One of Europe's original PDRN pharmaceutical manufacturers with decades of experience

Attribute	Rejuran	Mastelli
Origin	🇰🇷 South Korea	🇮🇹 Italy
Products in Catalog	6	2
Product Categories	ampoule, body-care, cleanser, cream	injectable, mesotherapy
Average Rating	4.3	4.3
Price Range	$40–60, $30–40, $50–70, $55–70, $45–65, $40–50	$250–500 per session
Official Website	Yes	Yes

Rejuran vs Mastelli: The Definitive Clinical PDRN Comparison

Rejuran

Mastelli

Key Differences

At a Glance

Verdict

Products Comparison

Rejuran (6)

Body Lotion c-PDRN

Cleansing Milk c-PDRN

Nutritive Cream c-PDRN

Recover c-PDRN Lifting Ampoule

Turnover Ampoule c-PDRN

UV Protection Cream SPF 50+ PA+++

Mastelli (2)

Plinest Body

Plinest Fast

Frequently Asked Questions

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