PDRN Facial: What It Is, Cost, Benefits & What to Expect

A typical PDRN facial begins with a double cleanse to remove makeup, sunscreen, and impurities, followed by a gentle exfoliation or aqua peel to prepare the skin for optimal PDRN absorption. Some clinics include extractions or a hydrating pre-treatment step at this stage.

The core of the treatment involves PDRN delivery into the dermis. The most common technique uses a series of superficial microinjections with a 30-32 gauge needle or an automated mesogun, depositing small blebs of PDRN solution across the entire face in a systematic pattern. The injections target just below the epidermis at a depth of 1-2mm. Alternative delivery methods include microneedling with PDRN solution or electroporation devices that enhance transdermal penetration without needles.

After PDRN delivery, the practitioner typically applies a soothing and hydrating mask — often containing additional growth factors or hyaluronic acid — which is left on for 10-15 minutes. Many clinics conclude the facial with LED light therapy (red or near-infrared wavelengths) to further stimulate collagen production and reduce any post-treatment inflammation. A final application of moisturizer and sunscreen completes the session. The entire procedure takes 45-75 minutes. Patients are advised to avoid makeup for 12-24 hours, skip active ingredients (retinoids, acids) for 48 hours, and apply sunscreen diligently.