PDRN Calming Serum

Isntree

Isntree's PDRN Calming Serum brings the brand's minimalist, ingredient-conscious philosophy to the PDRN category. Built around salmon-derived polydeoxyribonucleotide at a functional concentration, the formula activates the adenosine A2A receptor pathway to stimulate fibroblast proliferation and suppress pro-inflammatory cytokines — delivering both visible repair and immediate soothing relief for stressed, reactive skin. The supporting cast is carefully curated: Centella Asiatica extract and its key triterpenoids (madecassoside and asiaticoside) reinforce the anti-inflammatory action, while green tea catechins provide antioxidant protection against environmental aggressors. Panthenol strengthens the moisture barrier, and beta-glucan offers deep hydration without occlusion. The result is a serum that addresses redness, irritation, and micro-damage simultaneously. The texture is a translucent, slightly viscous fluid that spreads easily and absorbs within seconds, leaving no residue or tackiness. It layers beautifully under moisturizers and sunscreen, making it ideal for multi-step routines. The fragrance-free, low-pH formula has been patch-tested for sensitive skin and is free of alcohol, essential oils, and artificial colorants.