PDRN Midnight Blue Calming Cream

Dear, Klairs

Dear, Klairs PDRN Midnight Blue Calming Cream extends the brand's iconic Midnight Blue line with the addition of salmon-derived polydeoxyribonucleotide. The original Midnight Blue Calming Cream earned a devoted following for its ability to soothe irritated skin using guaiazulene — the compound that gives the cream its distinctive blue tint — and this PDRN-enhanced version adds a regenerative dimension to an already excellent calming formula. The science is complementary: guaiazulene, derived from chamomile, is a potent anti-inflammatory that reduces redness and irritation on contact. Centella Asiatica extract and its active triterpenoids (madecassic acid, asiaticoside) strengthen the skin barrier and promote wound healing. PDRN amplifies these effects at the cellular level by binding the adenosine A2A receptor, suppressing TNF-alpha and IL-6 production while stimulating fibroblast activity and collagen synthesis. The triple-calming approach — topical anti-inflammatory, barrier repair, and cellular regeneration — makes this one of the most comprehensive soothing creams in the K-beauty PDRN space. The texture is a medium-weight cream that absorbs well without greasiness. The characteristic blue color comes entirely from guaiazulene, not artificial dyes. At 60mL, the tube is sized for targeted facial use and travel convenience. True to the Klairs ethos, the formula is free of alcohol, parabens, artificial fragrance, and essential oils, and has been dermatologically tested for sensitive skin.