PDRN CarePDRN Facial: What It Is, Cost, Benefits & What to Expect
The PDRN facial has become one of the most sought-after aesthetic treatments in Korean dermatology and is rapidly gaining popularity worldwide. Often referred to as the 'salmon facial' or 'Rejuran facial,' this treatment delivers polydeoxyribonucleotide (PDRN) — a bioactive compound derived from salmon DNA — directly into the skin to stimulate regeneration at the cellular level. Unlike traditional facials that work on the skin surface with cleansing, exfoliation, and topical products, a PDRN facial penetrates the dermal layer to activate the body's own repair mechanisms. The appeal of the PDRN facial lies in its ability to address multiple skin concerns simultaneously. Through adenosine A2A receptor activation, the treatment stimulates collagen and elastin production, increases hyaluronic acid synthesis for deep hydration, reduces inflammation, and supports cellular DNA repair. This translates to visible improvements in skin texture, firmness, hydration, fine lines, pore size, and overall radiance — the coveted 'glass skin' effect that Korean skincare is famous for. PDRN facials are available in several formats depending on the delivery method. The most common is microinjection using a fine needle or mesogun, which deposits small amounts of PDRN across the entire face in a grid pattern. Other variations include PDRN delivered via microneedling, aqua peel systems, or as part of a multi-step facial protocol that may include cleansing, exfoliation, PDRN application, and LED therapy. The treatment is suitable for virtually all skin types and ages. It is particularly popular among patients in their 30s-50s seeking to improve overall skin quality without the downtime of more aggressive procedures. Sessions typically take 30-60 minutes, with minimal downtime of 1-3 days of mild redness. A series of 3-5 treatments spaced 2-4 weeks apart is the standard protocol, with maintenance sessions every 2-3 months to sustain results.
How It Works
A typical PDRN facial begins with a double cleanse to remove makeup, sunscreen, and impurities, followed by a gentle exfoliation or aqua peel to prepare the skin for optimal PDRN absorption. Some clinics include extractions or a hydrating pre-treatment step at this stage. The core of the treatment involves PDRN delivery into the dermis. The most common technique uses a series of superficial microinjections with a 30-32 gauge needle or an automated mesogun, depositing small blebs of PDRN solution across the entire face in a systematic pattern. The injections target just below the epidermis at a depth of 1-2mm. Alternative delivery methods include microneedling with PDRN solution or electroporation devices that enhance transdermal penetration without needles. After PDRN delivery, the practitioner typically applies a soothing and hydrating mask — often containing additional growth factors or hyaluronic acid — which is left on for 10-15 minutes. Many clinics conclude the facial with LED light therapy (red or near-infrared wavelengths) to further stimulate collagen production and reduce any post-treatment inflammation. A final application of moisturizer and sunscreen completes the session. The entire procedure takes 45-75 minutes. Patients are advised to avoid makeup for 12-24 hours, skip active ingredients (retinoids, acids) for 48 hours, and apply sunscreen diligently.